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What are the benefits of quercetin for the human body?

 


Quercetin is a polyhydroxyflavonoid compound with various biological activities and high medicinal value. Quercetin is widely found in the flowers, leaves and fruits of plants. It is known that more than 100 kinds of Chinese herbal medicines contain quercetin, such as Sophora japonica, Sophora japonica, Paeonolus, Plantain, Ginkgo biloba, Acanthopanax senticosus, etc. It has anti-oxidative and free radical scavenging effects, as well as anti-cancer, anti-inflammatory, antibacterial, antiviral, hypoglycemic and antihypertensive, immune regulation and cardiovascular protection effects.

The effect of quercetin on the human body

1. The role of quercetin and respiratory health

Quercetin has good expectorant and antitussive effects, and has a certain antiasthmatic effect. It has been used for a long time in the treatment of chronic bronchitis. The effects of quercetin on respiratory health are achieved through multiple pathways including mucus secretion, anti-viral, anti-fibrotic, and anti-inflammatory.

Quercetin also has a wide range of anti-fibrotic effects, including anti-liver, lung, heart and kidney fibrosis, and its mechanism of action is complex, including inhibition of fibroblast proliferation, and inhibition of collagen synthesis, prevention of oxidative damage, inhibition of angiogenesis, etc. 

2. Antioxidant function of quercetin

Free radicals are normal metabolites in the body. When the free radicals in the body are excessive and unbalanced, it may lead to aging, inflammation, cancer, cardiovascular and cerebrovascular diseases, etc. Experiments have shown that flavonoids have good scavenging effects on free radicals and superoxide anions.

3. Anti-inflammatory effect

Quercetin reduces the body's immune response to allergens, inhibits IgE-mediated release of allergic mediators from mast cells and IgG-mediated histamine release, is a potent inhibitor of lipoxygenase, and reduces pro-inflammatory arachidonic Production of acid metabolites. In addition, quercetin can reduce the entry of highly antigenic proteins, antigens, and allergenic microorganisms into the body.

* Neutrophils are the most important inflammatory cells in the body's early inflammatory response, and they play a central role in the inflammatory response. Quercetin has no obvious effect on the spontaneous apoptosis of neutrophils, but it can inhibit the delay of spontaneous apoptosis of neutrophils caused by the inflammatory factor LPS; Sensitivity to inflammatory factors, so as to achieve the purpose of anti-inflammatory.


4. It has the function of skin coloring and skin protection.
The study found that the number of melanocytes increased significantly after the external application of quercetin in the epidermis of guinea pigs, which had a color-enhancing effect on the back skin of brown-yellow guinea pigs, and had the function of promoting the proliferation of melanocytes and the synthesis of melanin.
5. Cardiovascular protection
The role of quercetin in protecting cardiovascular is mainly reflected in five aspects:
A.Dilate blood vessels and lower blood pressure: For example, quercetin can inhibit the release of endothelin and reduce the tension of blood vessels, thereby lowering blood pressure.
B.Prevention and treatment of coronary heart disease: Through animal experiments, the functions of reducing the incidence and mortality of myocardial infarction and lowering blood sugar have also been found;
C.Relieve myocardial hypertrophy; quercetin can significantly inhibit the increase of total protein content of myocardial cells caused by angiotensin II, can significantly increase SOD activity, reduce MDA content, and has obvious preventive and therapeutic effects on myocardial cell hypertrophy.
D.Inhibit the proliferation and hypertrophy of vascular smooth muscle cells;
E.antithrombotic. Inhibition of thrombin causes the increase of platelet cytoplasmic free calcium [Ca2+], and inhibits platelet activation and aggregation, thereby indirectly protecting the cardiovascular system, dilating arteries, lowering blood pressure, anti-arrhythmic, inhibiting in vitro and in vivo Collagen, adenosine diphosphate, arachidonic acid (AA), etc. induce platelet aggregation and release of serotonin (5-HTP).


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